Development and evaluation of aceclofenac-loaded mucoadhesive microcapsules
نویسندگان
چکیده
منابع مشابه
Development and Evaluation of Amoxicillin Loaded Carbopol 934P Mucoadhesive Microcapsules for Sustained Drug Release for H. pylori Treatment
Amoxicillin (α-amino-p-hydroxybenzyl-penicillin) is a semi-synthetic, orally absorbed and widely prescribed β-lactam antibiotic. It is now widely used for eradication of gastric Helicobacter pylori infection combined with a second antibiotic and an acid‐suppressing agent despite its short elimination half-life of one hour. The purpose of this study was to develop and evaluate amoxicillin loaded...
متن کاملFormulation and In-vitro Evaluation of Aceclofenac Microcapsules
Aceclofenac was formulated as novel enteric microcapsules for improved delivery to the intestine using the polymer ethyl cellulose as the retardant material. Micro encapsulation of aceclofenac was done to achieve a controlled drug release profile suitable for per oral administration. Aceclofenac was used as core and microcapsules were prepared by an emulsion solvent evaporation method. The prep...
متن کاملDevelopment and Evaluation of Mucoadhesive Algino-HPMC Microparticulate System of Aceclofenac for Oral Sustained Drug Delivery
retardant. The gastric residence of conventional dosage form is typically short which transit rapidly through the small intestine in not more than 3h, thus rapid gastrointestinal (GI) transit phenomenon may consequently lead to reduction in the extent of absorption of various drugs. The present study was to develop mucoadhesive microsphere of aceclofenac and evaluate the effect of polymer conce...
متن کاملPreparation, characterization and evaluation of ranitidine hydrochloride-loaded mucoadhesive microspheres.
BACKGROUND Mucoadhesion enables localization of drugs to a defined region of the gastrointestinal tract through attractive interactions between polymers composing the drug delivery devices and the mucin layer of the intestinal epithelium. Thus, this approach can be used for enhancement of the oral bioavailability of the drug. OBJECTIVES The current communication deals with the development of ...
متن کاملFormulation and evaluation of Bacillus coagulans-loaded hypromellose mucoadhesive microspheres
Development of a novel delivery system has been attempted to deliver viable probiotic cells into the gut for a prolonged period of time while maintaining high numbers of viable cells within the formulation throughout the shelf-life of the product and during the gastrointestinal transit. Core mucoadhesive microspheres of Bacillus coagulans were developed employing several grades of hypromellose,...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
ژورنال
عنوان ژورنال: Journal of Advanced Pharmaceutical Technology & Research
سال: 2011
ISSN: 2231-4040
DOI: 10.4103/2231-4040.90881